FZD2 (frizzled class receptor 2) is a Wnt receptor that plays essential roles in both canonical and non-canonical Wnt signaling pathways across multiple developmental and pathological processes. The protein functions as a cell surface receptor that binds Wnt ligands and activates downstream signaling cascades 1. In lung development, FZD2 orchestrates canonical Wnt/β-catenin signaling essential for endothelial proliferation and vascular development, while simultaneously regulating mesenchymal cell proliferation and survival through non-canonical pathways 1. During mesoderm differentiation, FZD2 activation promotes sustained Wnt-β-catenin levels, specifically guiding cells toward paraxial mesoderm while blocking lateral mesoderm formation 2. In limb development, FZD2 mediates both β-catenin-dependent and -independent Wnt signaling pathways, controlling digit chondrocyte elongation and orientation 3. Pathogenic variants in FZD2 cause Robinow syndrome and omodysplasia type 2, characterized by skeletal limb and craniofacial defects 34. Clinically, FZD2 dysregulation contributes to various diseases including pulmonary fibrosis through epithelial-to-mesenchymal transition 5, renal fibrosis via alternative polyadenylation mechanisms 6, and cancer progression in tongue squamous cell carcinoma where it correlates with poor prognosis 7.