FZD8 is a Frizzled-class Wnt receptor that functions as a key component of the canonical Wnt signaling pathway 1. It acts as a receptor for Wnt proteins, including WNT3A, and works with co-receptors LRP5/LRP6 to trigger β-catenin-dependent signaling through formation of receptor-ligand complexes 1. FZD8 is also involved in non-canonical Wnt signaling pathways, such as the FZD8/FYN/STAT3 axis 2. In tissue physiology, FZD8 exhibits spatial zonation in the liver, with pericentral expression patterns that regulate hepatocyte metabolism and proliferation 3. It plays critical roles in stem cell maintenance and tissue regeneration: FZD8 is essential for intestinal crypt homeostasis and Lgr5+ intestinal stem cell function 4, and participates in ocular angiogenesis through the WNT3A-FZD8 pathway 5. Clinically, aberrant FZD8 signaling is implicated in multiple diseases. In cancer, FZD8 activation drives neuroendocrine differentiation in prostate cancer 2 and promotes metastatic breast carcinoma progression through β-catenin/TCF-mediated transcription 6. FZD8-specific antibodies have been developed to selectively block FZD8-mediated signaling for potential cancer therapeutics 7. Additionally, FZD8 is implicated in pathological ocular neovascularization associated with diabetic retinopathy and age-related macular degeneration 5.