GABRR3 encodes the rho3 subunit of gamma-aminobutyric acid type A (GABA-A) receptors, which are pentameric ligand-gated chloride channels that mediate inhibitory neurotransmission in the brain. The gene is located on chromosome 3-q13.3, distinct from the clustered GABRR1 and GABRR2 genes on chromosome 3 1. Rho-containing GABA receptors form homomeric chloride channels that respond to GABA binding, allowing chloride influx and neuronal hyperpolarization. GABRR3 has been investigated as a candidate gene in several neurological disorders. Genetic association studies have examined GABRR3 polymorphisms, particularly rs832032, in restless legs syndrome (RLS), with one study reporting increased frequency of the rs832032T allele in RLS patients 2, though this association was not replicated in a larger genome-wide association study 3. The gene has also been studied in essential tremor 4 and migraine 5, but no significant associations were found. Interestingly, a rare variant (p.V465A) in GABRR3 showed significant depletion in centenarians compared to controls, suggesting potential relevance to longevity 6. The gene's mRNA has been detected in platelets, indicating expression beyond the nervous system 7.