GAGE2D (G antigen 2D) is an X-linked gene with predicted protein binding capability based on GO annotations. Based on limited published evidence, GAGE2D was identified as a component of an overweight/obesity-associated gene signature in hepatocellular carcinoma (HCC), contributing to a 17-gene prognostic model that stratified patients into distinct risk groups with significant differences in overall survival 1. The gene's specific molecular function and tissue-specific roles remain largely uncharacterized in the available literature.