GAS2L2 (growth arrest specific 2 like 2) functions as a cytoskeletal cross-linking protein that regulates microtubule dynamics and ciliary function. The protein localizes to the apical surface of ciliated cells, specifically at basal bodies, basal feet, rootlets, and actin filaments 1. GAS2L2 regulates microtubule stability by interacting with microtubule plus-end tracking proteins and controls microtubule growth along actin stress fibers 2. Critically, GAS2L2 is essential for proper ciliary orientation and mucociliary clearance in respiratory epithelia 1. Loss-of-function mutations in GAS2L2 cause primary ciliary dyskinesia (PCD), a genetic disorder characterized by impaired ciliary function and chr17 airway disease 13. Patients with GAS2L2 mutations present with defective ciliary orientation, asynchronous and hyperkinetic ciliary beating patterns (19.8 Hz versus 15.8 Hz in controls), and impaired mucociliary clearance despite normal ciliary axoneme structure 1. The protein has also been associated with mucous otitis media, suggesting broader roles in ciliated epithelial function 4. Additionally, GAS2L2 variants have been identified in recurrent pregnancy loss, though the mechanistic connection requires further investigation 5. These findings establish GAS2L2 as a critical regulator of ciliary function with significant clinical implications for respiratory and potentially reproductive health.