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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
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GPR139
G protein-coupled receptor 139
Chromosome 16 Β· 16p12.3
NCBI Gene: 124274Ensembl: ENSG00000180269.8HGNC: HGNC:19995UniProt: A0A142CHG1
15PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Receptor
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
G protein-coupled receptor signaling pathwayphospholipase C-activating G protein-coupled receptor signaling pathwayneuropeptide receptor activityidentical protein bindingAbnormality of the skeletal systemrestless legs syndromeessential hypertensionobesity
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

G protein-coupled receptor 139

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
Abnormality of the skeletal systemOpen Targets
0.41Moderate
restless legs syndromeOpen Targets
0.33Weak
essential hypertensionOpen Targets
0.28Weak
obesityOpen Targets
0.27Weak
musculoskeletal system diseaseOpen Targets
0.26Weak
alcohol drinkingOpen Targets
0.22Weak
hypertensionOpen Targets
0.22Weak
placental retentionOpen Targets
0.19Weak
polypOpen Targets
0.18Weak
benign soft tissue neoplasmOpen Targets
0.16Weak
biliary tract diseaseOpen Targets
0.16Weak
overnutritionOpen Targets
0.08Suggestive
ovarian neoplasmOpen Targets
0.07Suggestive
type 2 diabetes mellitusOpen Targets
0.06Suggestive
coronary artery diseaseOpen Targets
0.05Suggestive
iron metabolism diseaseOpen Targets
0.05Suggestive
ankylosing spondylitisOpen Targets
0.04Suggestive
insomniaOpen Targets
0.03Suggestive
osteoarthritisOpen Targets
0.03Suggestive
knee fractureOpen Targets
0.02Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
MCHR2Shared pathway100%GNB1Protein interaction100%GNAI1Protein interaction100%GPR83Shared pathway67%TRHRShared pathway50%OXGR1Shared pathway50%
Tissue Expression6 tissues
Brain
100%
Heart
0%
Lung
0%
Bone Marrow
0%
Ovary
0%
Liver
0%
Gene Interaction Network
Click a node to explore
GPR139MCHR2GNB1GNAI1GPR83TRHROXGR1
PROTEIN STRUCTURE
Preparing viewer…
PDB7VUG Β· 3.20 Γ… Β· EM
View on RCSB β†—
Constraintβ“˜
LOEUFβ“˜
0.73LoF Tolerant
pLIβ“˜
0.11Tolerant
Observed/Expected LoF0.45 [0.29–0.73]
RankingsWhere GPR139 stands among ~20K protein-coding genes
  • #15,576of 20,598
    Most Researched15
  • #5,669of 17,882
    Most Constrained (LOEUF)0.73
Genes detectedGPR139
Sources retrieved0 papers
Response timeβ€”