MCHR2 (melanin concentrating hormone receptor 2) is a G protein-coupled receptor located on chromosome 6 that serves as one of two receptors for the neuropeptide melanin-concentrating hormone (MCH) 1. Unlike its homolog MCHR1, MCHR2 is expressed only in carnivores, primates, and humans 2. The receptor binds MCH with high affinity and signals through Gq protein activation, triggering phosphoinositide hydrolysis and intracellular calcium release 3. MCHR2 is distributed across multiple brain regions and participates in energy homeostasis regulation, feeding behavior, and metabolism 4. While MCH signaling through both receptors influences sleep-wake rhythms, anxiety, depression, and reproduction, the specific role of MCHR2 in these processes remains incompletely characterized due to limited animal models 2. Genetic studies identify MCHR2 associations with body mass index, particularly in younger individuals with atypical depression 5, though MCHR2 appears not to be a major contributor to human obesity phenotypes 6. A genome-wide association study variant in MCHR2-AS1 showed association with tic disorders, though this finding lacked replication 7. MCHR2 represents a potential therapeutic target for metabolic and psychiatric disorders involving energy balance dysregulation.