GPR62 is an orphan G protein-coupled receptor (GPCR) with constitutive ligand-independent signaling activity 1. The receptor shows spontaneous activation of both the Gq/11-inositol phosphate and Gs-cAMP signaling pathways, along with β-arrestin recruitment, leading to receptor internalization in endosomal compartments 1. GPR62 is broadly expressed in the human brain, including the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus 2. Functionally, GPR62 exhibits reciprocal modulation with the melatonin receptor MTNR1B through heteromerization, which inhibits melatonin-induced signaling 1. In thyroid cancer pathology, GPR62 functions as an oncogenic driver within the SNHG3/miR-339-5p/GPR62 regulatory axis; knockdown of GPR62 suppresses thyroid cancer cell proliferation, migration, and invasion 3. Given its constitutive signaling capacity and role in cancer progression, GPR62 represents a potential therapeutic target, though its endogenous ligand remains unidentified. The receptor is also implicated in neurodevelopmental and psychiatric disorders, including autism spectrum disorder 4, affective disorders 5, and various neurological conditions 6.