GPRIN2 (G protein regulated inducer of neurite outgrowth 2) is a protein involved in neurite outgrowth and neuron projection development 1. The gene encodes a protein that binds to other cellular proteins and localizes to the plasma membrane [GO annotations from provided data]. Recent evidence from the T2T-CHM13 reference genome assembly confirms that GPRIN2 has multiple functional copies in the human genome, with proteomics data supporting its active expression 1. Mechanistically, GPRIN2 functions through a PI3K signaling pathway that regulates cellular proliferation and migration 2. In lung adenocarcinoma, GPRIN2 acts downstream of ferredoxin 1 (FDX1) to promote tumor cell proliferation, migration, and invasion; depletion of GPRIN2 reverses these pro-tumorigenic effects 2. Clinically, GPRIN2 variants are associated with multiple cancer types. Rare germline mutations in GPRIN2 are linked to familial esophageal squamous cell carcinoma risk 3, while somatic mutations appear in non-small-cell lung carcinoma across both adenocarcinoma and squamous cell carcinoma subtypes 4. GPRIN2 also functions as a mitophagy-related biomarker in psoriasis, where it correlates with disease severity and immune cell infiltration 5. Additionally, GPRIN2 variants are associated with breast cancer predisposition 6 and bipolar disorder genetic risk 7. These findings suggest GPRIN2 represents a pleiotropic gene with diverse roles in cancer development and neuropsychiatric disease.