BICDL1 (BICD family like cargo adaptor 1) is a dynein-dynactin adaptor protein that regulates intracellular transport and cell proliferation. Functionally, BICDL1 converts dynein into a highly processive motor by facilitating dynein-dynactin interaction and can recruit multiple dyneins to increase transport force and speed 1. In developing neurons, BICDL1 regulates secretory vesicle transport by controlling Rab6-containing vesicle accumulation in the pericentrosomal region, thereby restricting anterograde secretory transport and inhibiting neurite outgrowth during early neuronal differentiation 2. Clinically, BICDL1 overexpression is associated with poor prognosis in multiple cancers. In breast cancer, elevated BICDL1 promotes cell proliferation, migration, and invasion by suppressing pyroptosis—a programmed cell death pathway—through inhibition of NLRP3 inflammasome activation and reduced expression of pyroptosis-related proteins 3. Similarly, in colorectal cancer, BICDL1 overexpression correlates with reduced overall survival and is associated with altered immune infiltration patterns, including increased regulatory T cells and reduced helper T cell infiltration 4. These findings position BICDL1 as a potential prognostic biomarker and therapeutic target in cancer treatment.