FRY (FRY microtubule binding protein) is a conserved Furry family protein essential for proper cellular and organismal development. Functionally, FRY plays a crucial role in maintaining mitotic centrosome structural integrity and spindle bipolarity by promoting PLK1 activity at spindle poles during early mitosis, potentially functioning as a scaffold that enhances AURKA-mediated PLK1 phosphorylation. Beyond mitotic functions, FRY is expressed in multiple tissues including the central nervous system, where it is localized to neurons, and is required for proper development of neural and sensory structures. Loss-of-function variants in FRYL, the human ortholog, are associated with a dominant developmental disorder characterized by developmental delay, intellectual disability, dysmorphic features, and congenital anomalies affecting multiple organ systems 1. Animal models demonstrate that complete loss of FRY function is lethal at various developmental stages, while tissue-specific loss causes defects in wing and eye development 1. The protein appears to function through haploinsufficiency, where partial loss of function impairs normal development. These findings establish FRY as an intolerant-to-loss-of-function protein critical for both cell division machinery and neural development, with clinical relevance to neurodevelopmental disorders.