GPX6 (glutathione peroxidase 6) is a selenoprotein encoded on chromosome 6 that functions as a glutathione peroxidase enzyme involved in cellular redox homeostasis 1. As a selenium-containing protein, GPX6 reduces hydroperoxides to corresponding alcohols using glutathione as a cofactor, contributing to antioxidant defense mechanisms 2. GPX6 is notably restricted to the olfactory system in humans 2, though it exhibits broader tissue expression patterns in other species. The enzyme plays an antioxidative role in response to oxidative stress 3, participating in ROS-mediated inflammation reduction and cellular defense mechanisms 3. However, specific physiological functions of GPX6 remain incompletely characterized compared to other glutathione peroxidases 4. Clinically, GPX6 variants have been associated with epithelial ovarian cancer risk, particularly for the serous ovarian cancer subtype 5. In metabolic disease contexts, GPX6 expression is regulated in response to dietary stress and hepatic pathology; PGAM5 deletion increased GPX6 expression in high-fat/high-fructose diet models, suggesting involvement in metabolic stress responses 6. GPX6 expression is also responsive to selenium availability, highlighting its dependence on adequate selenium nutrition 7. Further research using knockout models is needed to fully elucidate GPX6's specific cellular functions and disease relevance.