GPX8 (glutathione peroxidase 8) is a type II transmembrane protein localized to the endoplasmic reticulum that belongs to the non-selenium-containing glutathione peroxidase family 1. While its precise biochemical function remains incompletely understood, GPX8 appears to play roles in cellular redox homeostasis and oxidative stress responses 2. The protein exhibits peroxidase activity and is proposed to be involved in protein folding processes within the ER, though this function awaits full elucidation 3. GPX8 has emerged as a significant factor in cancer biology, with overexpression associated with poor prognosis in multiple tumor types including gastric adenocarcinoma, gliomas, and osteosarcoma 145. In clear cell renal cell carcinoma, GPX8 promotes tumorigenesis by regulating lipogenesis through the NNMT pathway via IL6-STAT3 signaling 6. The protein influences cancer cell proliferation, migration, and invasion, and its deficiency can induce oxidative stress that reprograms the m6A epitranscriptome 2. GPX8 expression is transcriptionally regulated by factors such as KLF16 and appears to modulate immune cell infiltration in tumors 51. These findings position GPX8 as a potential therapeutic target and prognostic biomarker in cancer treatment.