GSK3A is a constitutively active serine/threonine kinase that functions as a negative regulator of multiple cellular pathways 123. In glucose homeostasis, GSK3A phosphorylates and inhibits glycogen synthase (GYS1/GYS2), suppressing glycogen synthesis and contributing to insulin resistance 123. GSK3A regulates Wnt signaling by phosphorylating beta-catenin and other components, controlling transcriptional activity 4. The kinase facilitates amyloid precursor protein processing and amyloid-beta generation implicated in Alzheimer's disease 56. Recent evidence reveals GSK3A's role in immune evasion: it inhibits cytotoxic T lymphocyte function by promoting neutrophil chemotaxis and extracellular trap formation through the LRG1 pathway, making it a therapeutic target for enhancing immunotherapy efficacy 7. GSK3A also acts as a proviral host factor for human adenovirus replication by phosphorylating viral L4-22K protein 8. Additionally, GSK3A regulates 3D genome architecture in a cohesin-dependent manner 9, and isoform-specific GSK3A inhibition correlates with improved human sperm motility 10. Genetically proxied GSK3A levels associate with reduced prostate cancer risk 11. These diverse functions position GSK3A as a multi-pathway regulator with significant clinical implications.