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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
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GSKIP
GSK3B interacting protein
Chromosome 14 Β· 14q32.2
NCBI Gene: 51527Ensembl: ENSG00000100744.16HGNC: HGNC:20343UniProt: Q9P0R6
36PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
beta-catenin bindingprotein kinase inhibitor activityprotein bindingpositive regulation of canonical Wnt signaling pathwaySjogren syndromeneurodegenerative diseasemeningiomaCongenital pulmonary alveolar proteinosis
✦AI Summary

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GSK3B interacting protein

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
Sjogren syndromeOpen Targets
0.09Suggestive
neurodegenerative diseaseOpen Targets
0.07Suggestive
meningiomaOpen Targets
0.05Suggestive
Congenital pulmonary alveolar proteinosisOpen Targets
0.04Suggestive
Neonatal acute respiratory distress with surfactant metabolism deficiencyOpen Targets
0.04Suggestive
surfactant metabolism dysfunction, pulmonary, 1Open Targets
0.03Suggestive
Alzheimer diseaseOpen Targets
0.03Suggestive
heart diseaseOpen Targets
0.03Suggestive
alcohol drinkingOpen Targets
0.03Suggestive
polycythemiaOpen Targets
0.02Suggestive
non-small cell lung carcinomaOpen Targets
0.02Suggestive
Nijmegen breakage syndromeOpen Targets
0.02Suggestive
Respiratory insufficiencyOpen Targets
0.02Suggestive
neoplasmOpen Targets
0.01Suggestive
neuroblastomaOpen Targets
0.01Suggestive
myeloid neoplasmOpen Targets
0.01Suggestive
Abnormal sperm morphologyOpen Targets
0.01Suggestive
astrocytomaOpen Targets
0.01Suggestive
ovarian carcinomaOpen Targets
0.01Suggestive
hepatocellular carcinomaOpen Targets
0.01Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
PRKACBProtein interaction99%PRKACGProtein interaction97%GSK3AProtein interaction85%GSK3BProtein interaction85%ATG2BProtein interaction79%PRKACAProtein interaction76%
Tissue Expression6 tissues
Bone Marrow
100%
Brain
88%
Liver
79%
Heart
60%
Lung
29%
Ovary
18%
Gene Interaction Network
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GSKIPPRKACBPRKACGGSK3AGSK3BATG2BPRKACA
PROTEIN STRUCTURE
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PDB1SGO Β· NMR
View on RCSB β†—
Constraintβ“˜
LOEUFβ“˜
0.86LoF Tolerant
pLIβ“˜
0.52Intermediate
Observed/Expected LoF0.33 [0.15–0.86]
RankingsWhere GSKIP stands among ~20K protein-coding genes
  • #10,785of 20,598
    Most Researched36
  • #7,537of 17,882
    Most Constrained (LOEUF)0.86
Genes detectedGSKIP
Sources retrieved0 papers
Response timeβ€”