IFT20 is an essential component of intraflagellar transport (IFT) particles that regulates ciliogenesis and ciliary function across multiple cell types. The protein coordinates with other IFT components, particularly IFT88 and IFT140, to control their levels and localization at the basal body and ciliary axoneme, which is crucial for proper ciliogenesis 1. IFT20 functions in trafficking ciliary proteins from the Golgi complex to cilia and regulates ciliary dynamics by modulating protein transport 2. In retinal pigment epithelium, conditional knockout of IFT20 ablates primary cilia, leading to defective RPE function, photoreceptor degeneration, and vision impairment 3. The protein also plays important roles in male fertility through spermatogenesis and flagella formation, with CEP78 acting as an interacting partner 4. Beyond ciliary functions, IFT20 has clinical relevance in cancer biology, where it confers paclitaxel resistance in breast cancer by modulating ASK1 signaling through β-arrestin-1 5. In lung adenocarcinoma, higher IFT20 expression correlates with better prognosis and reduced tumor aggressiveness 6. The gene is expressed across multiple human tissues including brain, lung, kidney, and pancreas 7.