ING3 (inhibitor of growth family member 3) functions as an epigenetic regulator that reads histone modifications, specifically recognizing trimethylated lysine 4 of histone H3 (H3K4Me3) through its plant homeodomain 1. The protein exhibits complex, context-dependent roles in cancer biology. In normal tissues, ING3 is highly expressed in rapidly proliferating cells such as those in small intestine, bone marrow, and epidermis, suggesting involvement in cellular growth and self-renewal 1. However, ING3 demonstrates both tumor suppressive and oncogenic properties depending on cancer type. It acts as a tumor suppressor in hepatocellular carcinoma, head and neck squamous cell carcinoma, and lung adenocarcinoma, where reduced expression correlates with aggressive tumor behavior and poor prognosis 234. Conversely, ING3 functions as an oncoprotein in prostate cancer, where overexpression stimulates cellular proliferation and correlates with poorer patient survival 5. Mechanistically, ING3 regulates cell cycle progression, apoptosis, and transcriptional programs by associating with chr7 modifiers 5. The protein undergoes degradation through the SCF(Skp2)-mediated ubiquitin-proteasome pathway, and its stability affects tumor suppressive functions 6. These findings highlight ING3's dual role as both a tumor suppressor and oncogene, depending on cellular context.