ING5 is a chr2-regulatory protein that functions as a component of histone acetyltransferase complexes, particularly the HBO1 (KAT7) and MOZ/MORF complexes 1. ING5 specifically mediates histone H3 lysine 14 acetylation (H3K14ac) and contributes to histone H4 acetylation, which regulates DNA replication and transcription 2. The protein inhibits cell growth, delays S-phase progression, and enhances apoptosis through INCA1-dependent mechanisms 3. Beyond its classical tumor-suppressor role, ING5 exhibits multifaceted biological functions including regulation of cell cycle, DNA damage response, and stem cell differentiation 4. In cardiac physiology, ING5 participates in cardiomyocyte proliferation control through the LRP6/ING5/P21 signaling pathway, with therapeutic potential for myocardial regeneration 5. ING5 is aberrantly expressed in various cancers, notably breast (79.9%), colorectal (56.3%), and endometrial carcinomas (50.0%), where it modulates tumor cell proliferation and chemoresistance 6. Recent studies identify ING5's PHD domain as a potential therapeutic target in leukemia when combined with other KAT7 complex member inhibition 7. Furthermore, ING5 regulates metabolic pathways, vascular function, and immune tolerance through HBO1-mediated chr2 modifications 8. These findings establish ING5 as a promising target for cancer therapy and regenerative medicine applications.