INO80B is a core subunit of the INO80 chr2 remodeling complex involved in transcriptional regulation, DNA replication, and DNA repair. 1 The complex functions by occupying enhancer and superenhancer regions to reduce nucleosome occupancy and facilitate transcription factor and Mediator recruitment, thereby promoting gene expression. 2 INO80B has emerged as a significant disease susceptibility gene across multiple conditions. In benign prostatic hyperplasia (BPH), INO80B expression is associated with disease risk, potentially through regulation of cell cycle-related genes that prevent excessive prostatic cell proliferation. 3 In pre-eclampsia, a susceptibility allele (rs34174194) in the INO80B 3'-UTR reduces miR-1324-mediated silencing, leading to increased INO80B expression in placental cells and disrupted trophoblast differentiation. 4 High INO80B expression correlates with poor prognosis in non-small cell lung cancer and melanoma, where the INO80 complex supports oncogenic transcription programs. 1 2 Additionally, INO80B appears in cuproptosis-related prognostic models for gastric cancer. 5 These findings indicate INO80B functions as both a disease susceptibility locus and a potential therapeutic target, with its expression levels critically influencing normal developmental processes and cancer progression.