JADE3 is a scaffold protein and crucial co-factor of the HBO1 histone acetyltransferase complex, functioning primarily in chrX regulation and transcriptional control 1. As a member of the JADE family of PHD finger proteins, JADE3 contains tandem Plant Homeo-domains that are essential for enhancing HBO1-mediated histone H4 acetylation and chrX remodeling 1. Beyond its canonical chrX-regulatory role, JADE3 has emerged as a multifunctional regulator with distinct disease-specific functions. In antiviral immunity, JADE3 activates NF-κB signaling to drive IFITM3 expression, restricting influenza A virus infection 2. In cancer biology, JADE3 promotes oncogenic properties: it increases cancer stem cell-like traits in colon cancer through Wnt/β-catenin-mediated upregulation and LGR5 transcriptional activation 3, while also predicting adverse outcomes in low-grade gliomas where JADE3 knockdown impairs glioma cell invasion and proliferation 4. Clinically, JADE3 mutations show sex-specific survival associations in clear cell renal cell carcinoma 5 and are identified as prognostic markers in diffuse large B-cell lymphoma 6. These findings suggest JADE3 as a potential therapeutic target across multiple cancer types and viral infections.