IQCC (IQ motif containing C) is a protein-coding gene located on chromosome 1 with established protein binding function based on GO annotations. Limited research exists on IQCC's specific molecular functions and mechanisms. However, IQCC has emerged as a potential biomarker in cancer contexts. In breast cancer research, IQCC was identified as one of six proteins (along with GELS, DAPLE, HS90B, A1AT, and CATD) that are upregulated in early-grade tumor tissue and detectable in patient serum, suggesting its utility as part of an early diagnostic biomarker signature 1. Additionally, IQCC was incorporated into a 9-gene stemness-based prognostic signature for gastric cancer, where it contributes to predicting patient prognosis and immunotherapy responsiveness 2. The stemness signature containing IQCC showed negative correlation with immune infiltration and was associated with immune escape mechanisms in high-risk patients 2. While these studies demonstrate IQCC's potential clinical relevance as a biomarker, the specific molecular mechanisms by which IQCC functions remain unclear. Further research is needed to elucidate IQCC's precise biological role, protein interactions, and contribution to cellular processes in both normal physiology and disease states.