1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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29PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingnucleusnucleoplasmmitotic spindleneurodegenerative diseaseknee fractureplacenta praeviaheart failure
Based on limited published evidence, KATNBL1 is a regulatory subunit that controls microtubule-severing activity of katanin A subunits (KATNA1 and KATNAL1) in a concentration-dependent manner. KATNBL1 localizes to spindle poles during mitosis and associates with katanin catalytic subunits to regulate their microtubule-severing function 1. During interphase, KATNBL1 is sequestered in the nucleus via an N-terminal nuclear localization signal and may coordinate with KATNB1 to modulate katanin activity during cell division and microtubule remodeling 1.
1
KATNBL1 regulates KATNA1 and KATNAL1 microtubule-severing activity, localizes to spindle poles during mitosis, contains nuclear localization signal, and coordinates with KATNB1
PMID: 26929214⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
neurodegenerative diseaseOpen Targets
knee fractureOpen Targets
placenta praeviaOpen Targets
Abruptio PlacentaeOpen Targets
heart failureOpen Targets
diabetic ketoacidosisOpen Targets
major depressive disorderOpen Targets
acute myeloid leukemiaOpen Targets
cervical cancerOpen Targets
colon adenocarcinomaOpen Targets
colorectal adenocarcinomaOpen Targets
esophageal cancerOpen Targets
gastric cancerOpen Targets
ovarian serous cystadenocarcinomaOpen Targets
urinary bladder cancerOpen Targets
Uterine CarcinosarcomaOpen Targets
uterine corpus endometrial carcinomaOpen Targets
No pathogenic variants reported on ClinVar for this gene.