KCNA10 encodes a voltage-gated potassium channel that exhibits unique dual regulation by both voltage and cyclic nucleotides, specifically cGMP 1. The channel mediates selective potassium ion permeability across excitable membranes, allowing K+ flow down electrochemical gradients when activated by membrane voltage changes. KCNA10 demonstrates tissue-specific expression patterns, with prominent localization at the apical membrane of renal proximal tubular cells and in glomerular endothelium 2. In the kidney, the channel likely stabilizes membrane potential to facilitate proximal tubular sodium absorption, while its presence in vascular endothelial and smooth muscle cells suggests a role in vascular tone regulation 2 3. Disease associations include chr1 kidney disease of unknown etiology, where specific polymorphisms (rs34970857) significantly increase susceptibility 4. KCNA10 variants are also implicated in neurological conditions, with associations found in Parkinson's disease, chr1 dry cough, and ACE inhibitor-induced cough through neuronal dysfunction pathways 5 6. Additionally, KCNA10 shows differential expression in oral squamous cell carcinoma and undergoes downregulation during vestibular hair cell stress responses to ototoxic compounds 7 8. The gene maps to chromosome 1.1 1.