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10 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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KCP
kielin cysteine rich BMP regulator
Chromosome 7 · 7q32.1
NCBI Gene: 375616Ensembl: ENSG00000135253.16HGNC: HGNC:17585UniProt: A0A087WVT8
5PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
positive regulation of BMP signaling pathwayextracellular regionneurodegenerative diseasebrain diseasesystemic lupus erythematosusCOVID-19
✦AI Summary

I cannot provide an accurate gene function summary for KCP (kielin cysteine rich BMP regulator) based on the provided abstracts. None of the PubMed abstracts supplied contain information about KCP's biological function, mechanism, or disease relevance. The abstracts discuss unrelated topics including tirzepatide for pediatric diabetes 1, chr7 pruritus management 2, chr7 prurigo 3, sensitive skin 4, tenapanor for hyperphosphatemia 5, chr7 prurigo treatment 6, Kaposi's sarcoma-associated herpesvirus complement control protein 7, and prurigo nodularis immune signatures 8. While the NCBI summary indicates KCP enhances BMP signaling and inhibits activin-A and TGFB1 pathways, and GO annotations confirm extracellular localization with positive regulation of BMP signaling, these sources are not grounded in the provided PubMed literature. To generate a properly cited summary, abstracts directly investigating KCP's molecular function, signaling mechanisms, and clinical disease associations would be required.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
neurodegenerative diseaseOpen Targets
0.40Weak
brain diseaseOpen Targets
0.27Weak
systemic lupus erythematosusOpen Targets
0.16Weak
COVID-19Open Targets
0.15Weak
renal carcinomaOpen Targets
0.10Weak
psoriasisOpen Targets
0.10Weak
neoplasmOpen Targets
0.08Suggestive
ulcerative colitisOpen Targets
0.06Suggestive
goutOpen Targets
0.06Suggestive
clear cell renal carcinomaOpen Targets
0.04Suggestive
papillary renal cell carcinomaOpen Targets
0.04Suggestive
inflammatory bowel diseaseOpen Targets
0.04Suggestive
rheumatoid arthritisOpen Targets
0.04Suggestive
Oral ulcerOpen Targets
0.04Suggestive
Dent diseaseOpen Targets
0.04Suggestive
Dent disease type 1Open Targets
0.04Suggestive
Sjogren syndromeOpen Targets
0.04Suggestive
hypothyroidismOpen Targets
0.04Suggestive
familial juvenile hyperuricemic nephropathy type 2Open Targets
0.04Suggestive
Hyperuricemia - anemia - renal failureOpen Targets
0.04Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
BMP7Protein interaction76%ARK2CShared pathway50%ELAPOR2Shared pathway50%NGLY1Shared pathway33%SCUBE3Shared pathway33%UBE2OShared pathway25%
Tissue Expression6 tissues
Lung
100%
Heart
50%
Bone Marrow
34%
Liver
23%
Ovary
16%
Brain
11%
Gene Interaction Network
Click a node to explore
KCPBMP7ARK2CELAPOR2NGLY1SCUBE3UBE2O
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt Q6ZWJ8
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
1.12LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF1.00 [0.88–1.12]
RankingsWhere KCP stands among ~20K protein-coding genes
  • #18,344of 20,598
    Most Researched5
  • #11,613of 17,882
    Most Constrained (LOEUF)1.12
Genes detectedKCP
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Atopic Dermatitis.
PMID: 33761208
N Engl J Med · 2021
1.00
2
Efficacy and safety of tirzepatide in children and adolescents with type 2 diabetes (SURPASS-PEDS): a randomised, double-blind, placebo-controlled, phase 3 trial.
PMID: 40975112
Lancet · 2025
0.90
3
S2k guideline: Diagnosis and treatment of chronic pruritus.
PMID: 36252071
J Dtsch Dermatol Ges · 2022
0.80
4
Chronic Prurigo.
PMID: 38722190
J Dtsch Dermatol Ges · 2024
0.70
5
Sensitive skin.
PMID: 26805416
J Eur Acad Dermatol Venereol · 2016
0.60