KIF3C (kinesin family member 3C) is a microtubule-based motor protein that functions as an anterograde translocator for membranous organelles 1. The protein contains a conserved motor domain and exhibits microtubule-binding and ATP hydrolysis activities critical for cytoskeletal motor function 2. KIF3C localizes to chromosome 2 and is preferentially expressed in the brain 1. Mechanistically, KIF3C operates through the PI3K/AKT signaling pathway across multiple cancer contexts 34. In lung squamous cell carcinoma, KIF3C-mediated EGFR-endosomal recycling is enhanced by VASH2-induced tubulin detyrosination, prolonging PI3K/Akt/mTOR activation 5. KIF3C also participates in epithelial-mesenchymal transition (EMT) through upregulation of EMT markers 3. Clinically, KIF3C is significantly elevated across multiple cancer types and serves as a prognostic biomarker correlating with unfavorable outcomes, reduced overall survival, disease-specific survival, and progression-free survival 6. In colorectal and gastric cancers, KIF3C promotes proliferation, migration, and invasion while reducing apoptosis 46. Additionally, KIF3C amplification via extrachromosomal circular DNA (eccDNA) contributes to proteasome inhibitor resistance in multiple myeloma 7. Pathogenic KIF3C mutations combined with ZNF513 mutations cause hereditary gingival fibromatosis through dysregulation of fibroblast proliferation and fibrosis pathways 8.