Based on limited published evidence, DYNLT4 encodes a dynein light chain protein functioning as a component of the cytoplasmic dynein complex involved in microtubule-based movement. Database annotations indicate roles in protein binding, dynein intermediate chain binding, and localization to the axoneme, sperm flagellum, and nucleus. Recent studies identified DYNLT4 associations with Alzheimer's disease protection through gene-based testing 1, and demonstrated that DYNLT4 degradation via the Mid1-mediated ubiquitin-proteasome pathway impairs retrograde axonal transport in hippocampal neurons, affecting learning and memory 2.