DYNLT2 (dynein light chain Tctex-type 2), also known as TCTE3, is a structural component of cytoplasmic dynein complexes essential for microtubule-based motor function 1. As a dynein light chain, it contributes to the structural and functional integrity of cilia and flagella, tissues where it is specifically expressed 1. DYNLT2 plays a critical role in sperm flagellar function and motility; reduced expression is significantly associated with asthenozoospermia (reduced sperm motility) and terato-asthenozoospermia 2. Age-related proteomic studies demonstrate higher DYNLT2 expression in young adult spermatozoa compared to advanced age groups, correlating with age-associated fertility decline 3. Clinically, DYNLT2 haploinsufficiency through 6q27 deletions has been implicated in developmental disorders, including a case of 6q27 deletion syndrome presenting with epilepsy, intellectual disability, and metabolic dysfunction 4. Additionally, heterozygous TCTE3 deletions have been identified in congenital diaphragmatic hernia patients, suggesting DYNLT2 may influence ciliary-dependent developmental processes 5. While initial mutational screening did not identify DYNLT2 as a major primary ciliary dyskinesia gene 1, its role in male fertility and developmental morphogenesis remains clinically significant.