KLHL36 (kelch-like family member 36) functions as a probable substrate-specific adapter of Cul3-RING E3 ubiquitin ligase complexes, mediating ubiquitination and proteasomal degradation of target proteins [UniProt annotation]. The gene exhibits cullin family protein binding activity and participates in proteasome-mediated ubiquitin-dependent protein catabolic processes [GO annotations]. Genetically, KLHL36 has been identified as a genome-wide significant locus associated with psychological resilience in U.S. Army soldiers 1, with variants detected at gene-wise significance (p = 1.89 × 10⁻⁶) in self-assessed resilience measures. This finding has been corroborated in independent research highlighting KLHL36 as one of three susceptibility loci for resilience alongside DCLK2 and SLC15A5 2. The gene's role in resilience suggests potential relevance to stress-related psychiatric disorders including posttraumatic stress disorder and depression. Transcriptomically, KLHL36 expression is modulated in disease contexts: it is upregulated by TNFα in triple-negative breast cancer cells and downregulated by the dietary flavonoid apigenin 3. Additionally, KLHL36 has been identified as a predictive marker for FOLFOX chemotherapy response in colorectal cancer patients, with dysregulation associated with treatment resistance 4. Gene-based analyses have also implicated KLHL36 in suicide risk through altered brain expression patterns 5.