LTBP2 (latent transforming growth factor beta binding protein 2) is an extracellular matrix protein that plays a critical structural role in elastic fiber organization and microfibril assembly 1. The protein functions as a binding partner for latent TGF-β, modulating transforming growth factor beta signaling pathways and regulating collagen biosynthesis and extracellular matrix organization 23. LTBP2 is translationally regulated by EPRS during cardiac fibrogenesis, with upregulation identified as a key proline-rich profibrotic gene alongside collagens 3. Clinically, LTBP2 mutations are associated with connective tissue disorders including Weill-Marchesani syndrome, primary congenital glaucoma, and Marfan-like syndromes with ocular manifestations 4. Beyond genetic disease, LTBP2 exhibits pathological roles in acquired conditions: it is secreted by cancer-associated fibroblasts in esophageal cancer, where it promotes metastasis and chemoresistance via integrin α6β4-Src signaling activation 5. In colorectal cancer liver metastases, LTBP2+ CAFs modulate collagen biosynthesis and ECM organization, making LTBP2 a potential therapeutic target 6. Additionally, LTBP2 is upregulated in activated hepatic stellate cells during liver fibrosis 2 and identified as a biomarker for dementia prediction in plasma proteomics 7.