LUZP1 (leucine zipper protein 1) is a multifunctional cytoskeletal regulator that primarily functions as an F-actin cross-linking protein involved in cellular architecture and contractility 1. The protein stabilizes actin filaments and serves as a negative regulator of primary cilium formation by modulating actin dynamics and mobilizing ARP2 to centrosomes 1. LUZP1 localizes to both actin filaments and centrosomes/basal bodies, where it promotes epithelial cell apical constriction through microtubule-dependent inhibition of myosin phosphatase, thereby maintaining elevated levels of diphosphorylated myosin light chain 2. The protein also regulates cytokinesis by inhibiting myosin light chain phosphorylation and suppressing contractile ring constriction velocity 3. Disease relevance includes potential contributions to 1p36 deletion syndrome, as LUZP1 is located within the critical chr1 region associated with this developmental disorder 4. Additionally, LUZP1 has been implicated in Townes-Brocks Syndrome through interactions with truncated SALL1 protein 5. Clinically, dysregulated LUZP1 expression has been associated with various cancers, including roles in triple-negative breast cancer migration through DAPK3 interactions 3 and involvement in osteosarcoma progression and glioma regulation 67, highlighting its potential as a therapeutic target.