ODF2L (outer dense fiber of sperm tails 2-like) is a centriolar satellite protein that functions primarily as a suppressor of ciliogenesis initiation 1. As a ciliation inhibitor, ODF2L exists in multiple isoforms with distinct roles: both isoforms are required to prevent ciliogenesis, while one additionally regulates cilium length post-initiation 1. Mechanistically, ODF2L licenses the recruitment of PKMYT1 to the CDK1-cyclin B complex, restricting CDK1 activity during cell cycle regulation 2. Clinically, ODF2L expression correlates with cancer outcomes and immune function. In epithelial ovarian cancer, low ODF2L levels predict sensitivity to WEE1 inhibition, with ODF2L knockdown causing accumulated DNA damage and synergistic tumor growth reduction when combined with WEE1 inhibitors 2. In colorectal cancer, the rs4288573 C allele variant associates with poor progression-free and overall survival following irinotecan chemotherapy, with elevated ODF2L expression promoting chemoresistance 3. Additionally, ODF2L serves as a biomarker in tear-derived extracellular vesicles for diabetic retinopathy diagnosis 4, and functions as a CD4+ T-cell marker associated with pulmonary tuberculosis risk 5. These findings position ODF2L as both a ciliogenesis regulator and a candidate therapeutic target in cancer precision medicine.