MAP1A (microtubule-associated protein 1A) is a brain-specific structural protein that plays critical roles in neuronal development and microtubule stabilization 1. The protein contains 2805 amino acids and includes conserved tubulin binding motifs in its amino-terminal region, enabling it to bind along the microtubule lattice and stabilize microtubules in postnatal axons 1. MAP1A functions as a classical microtubule-associated protein involved in the formation and development of axons and dendrites 2. The protein undergoes post-translational cleavage into light and heavy chains, which assemble into mature complexes with the separately encoded LC3 subunit 2. MAP1A expression is predominantly restricted to mature neurons, contrasting with MAP1B which is highest in developing neurons 3. The gene shows approximately 10-fold greater expression in adult brain compared to fetal brain, with strong evolutionary conservation indicating functional importance 1. Beyond microtubule stabilization, MAP1A can interact with other cellular components including filamentous actin and signaling proteins, and its activity is regulated by upstream signaling pathways including MAP kinase and glycogen synthase kinase-3 beta 2. Recent studies have linked MAP1A to cellular aging processes and neuroprotection through interactions with osteopontin 45.