1 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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4PubMed Papers
12Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
K48-linked deubiquitinase activitycysteine-type deubiquitinase activityprotein K48-linked deubiquitinationAbnormality of the gastrointestinal tractovarian dysfunctionHirsutismskeletal system disease
Based on limited published evidence, MINDY4B encodes a protein with K48-linked deubiquitinase activity according to GO annotations. MINDY4B variants have been identified in association with visceral leishmaniasis relapse susceptibility in a whole-exome sequencing study 1, though the specific molecular mechanism underlying this association remains unclear. Further functional studies are needed to elucidate MINDY4B's role in immune response and disease pathogenesis.
1
MINDY4B variants were identified as correlating with visceral leishmaniasis relapse susceptibility in whole-exome sequencing analysis
PMID: 40020829⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
Abnormality of the gastrointestinal tractOpen Targets
ovarian dysfunctionOpen Targets
skeletal system diseaseOpen Targets
diabetes mellitusOpen Targets
glomerulonephritisOpen Targets
urinary tract obstructionOpen Targets
restless legs syndromeOpen Targets
central nervous system cancerOpen Targets
posterior cortical atrophyOpen Targets
systemic lupus erythematosusOpen Targets
No pathogenic variants reported on ClinVar for this gene.