MIPOL1 (Mirror-Image Polydactyly 1) is a gene encoding a 442-amino acid protein primarily associated with limb development and tumor suppression. The gene spans approximately 350 kb on chromosome 14, comprises 15 exons, and shows weak expression in adult heart, liver, skeletal muscle, kidney, and pancreas, with stronger expression in fetal kidney 1. During embryonic development, mouse Mipol1 is broadly expressed throughout E10.5-E13.5 embryos, suggesting roles in early developmental processes 1. MIPOL1 functions as a disease-causing gene for non-syndromic polydactyly, with disruptions leading to mirror-image polydactyly characterized by mirror-image duplication of digits 12. The protein localizes to both cytosol and nucleus and exhibits protein binding capabilities. Additionally, MIPOL1 acts as a tumor suppressor in nasopharyngeal carcinoma, where it is downregulated in tumor tissues 3. Re-expression of MIPOL1 inhibits angiogenesis and metastasis by downregulating angiogenic factors, reducing phosphorylation of metastasis-associated proteins (AKT, p65, FAK), and interacting with tumor suppressor RhoB to enhance its activity 3. MIPOL1 has also been identified as a prognostic marker in oral squamous cell carcinoma 4.