MMP14 (matrix metalloproteinase 14) is a membrane-anchored endopeptidase that degrades extracellular matrix components, particularly collagen, and is essential for pericellular collagenolysis and connective tissue modeling 1. As a key activator of progelatinase A/MMP2, MMP14 promotes cell growth and migration while regulating fibrovascular tissue formation 2. Beyond proteolysis, MMP14 functions as a multivalent signaling regulator: it cleaves PTK7 to modulate actin cytoskeleton reorganization, inhibits Notch signaling through DLL1 cleavage, releases vasculostatin-40 from ADGRB1 to suppress angiogenesis, and inactivates GFRAL to regulate GDF15 signaling 3456. Pathologically, MMP14 overexpression is associated with poor prognosis in gastric cancer, correlating with tumor invasion, metastasis, and advanced stage 78. In melanoma, VPS35/Retromer-mediated regulation of MMP14 subcellular localization controls metastatic dissemination 9. MMP14 also influences sarcoma progression through tumor microenvironment remodeling 10. Additionally, MMP14 integrin interactions within the tumor secretome regulate invasion and proteolytic modification of extracellular components 11. Gene polymorphisms in MMP14 associate with hepatocellular carcinoma capsule formation and cerebral stroke risk 1213.