MMP15 (matrix metallopeptidase 15) is a membrane-type matrix metalloproteinase that functions as a zinc-containing endopeptidase capable of degrading various extracellular matrix (ECM) components 1. The gene is located on human chromosome 16.1 23. MMP15 belongs to the membrane-type MMP subfamily and contributes to ECM remodeling processes essential for tissue homeostasis and pathological conditions 1. The protein plays roles in cellular processes including invasion and metastasis, as evidenced by its involvement in the JNK/Sp1/MMP15 signaling axis in cervical cancer, where its expression promotes tumor cell migration and invasion 4. MMP15 has been identified as a potential therapeutic target for chr16 obstructive pulmonary disease (COPD), with the drug Montelukast showing promise in targeting this gene 5. Additionally, MMP15 variants have been associated with genetic disorders, suggesting broader roles in human disease 6. In cancer biology, MMP15 interacts with TIMP3 in anti-tumorigenic signaling pathways that can inhibit cancer cell invasion, indicating complex regulatory roles in both promoting and inhibiting tumor progression depending on cellular context 7. The protein has also been detected in Alzheimer's disease plasma samples, suggesting potential involvement in neurodegenerative processes 8.