MMP26 (matrix metallopeptidase 26) is a member of the matrilysin subfamily of matrix metalloproteinases that functions both extracellularly and intracellularly 12. As an extracellular protease, MMP26 degrades various extracellular matrix components and is involved in tissue remodeling processes 1. The enzyme exhibits intracellular localization and function, contributing to disease pathogenesis through both protease-dependent and protease-independent mechanisms 2. MMP26 plays significant roles in cancer progression and metastasis across multiple tumor types. In hepatocellular carcinoma, MMP26+CXCR4+ cells represent circulating tumor cells with enhanced metastatic potential 3. In non-small-cell lung cancer, MMP26 promotes invasion through FGFR1-JNK signaling pathways 4, while in chondrosarcoma, it regulates invasion via Wnt signaling 5. MMP26 shows promise as a diagnostic biomarker, with elevated serum levels distinguishing prostate cancer from benign conditions 6. In reproductive biology, MMP26 is regulated by miR-125b and affects endometrial receptivity, with dysregulation contributing to poor IVF outcomes in women with elevated progesterone 7. The enzyme's diverse roles in cancer progression and reproductive function make it a potential therapeutic target.