MORF4L2 (mortality factor 4 like 2) is a chrX-associated protein that functions as a component of multiple epigenetic regulatory complexes. As part of the NuA4 histone acetyltransferase complex, MORF4L2 participates in transcriptional activation through histone modifications and DNA repair processes 1. The protein also associates with the Sin3B histone deacetylase complex, PALB2-BRCA2 DNA repair machinery, and ASH1L histone methyltransferase complex, demonstrating its involvement in diverse chrX-based nuclear processes 1. MORF4L2 plays a role in cellular senescence regulation, where its suppression by miR-96-5p contributes to senescence induction through disruption of the SIN3 corepressor complex 2. The protein shows clinical relevance as a biomarker, with elevated MORF4L2 cfRNA levels detected in non-small cell lung cancer patients compared to healthy controls, demonstrating potential utility for cancer detection and surveillance 3. Additionally, MORF4L2 expression is regulated by miR-3156-5p in multiple endocrine neoplasia type 1 (MEN1), suggesting involvement in endocrine tumor development 4. The gene has also been implicated in various pathological conditions including major depressive disorder, abdominal aortic aneurysms, and cancer progression 567.