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GeneE
1 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
MRFAP1L1
Morf4 family associated protein 1 like 1
Chromosome 4 Β· 4p16.1
NCBI Gene: 114932Ensembl: ENSG00000178988.12HGNC: HGNC:28796UniProt: A0A075DDR2
25PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingidentical protein bindingtype 1 diabetes mellituspreeclampsiaovarian neoplasmataxia telangiectasia
✦AI Summary

Based on limited published evidence, MRFAP1L1 is a protein-binding protein belonging to the Morf4 family. Structurally, it exhibits identical protein binding and general protein binding capabilities according to Gene Ontology annotations. MRFAP1L1 was identified as a pyroptosis-related gene with significant expression differences between bladder cancer and normal tissue 1. It was selected as part of an 11-gene prognostic signature for predicting bladder cancer patient outcomes and survival, though its specific molecular mechanism remains undefined.

Sources cited
1
MRFAP1L1 identified as pyroptosis-related gene with differential expression in bladder cancer; included in prognostic risk model for predicting patient survival
PMID: 37849225
⚠Limited data available β€” This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
type 1 diabetes mellitusOpen Targets
0.06Suggestive
preeclampsiaOpen Targets
0.05Suggestive
ovarian neoplasmOpen Targets
0.02Suggestive
ataxia telangiectasiaOpen Targets
0.01Suggestive
ovarian carcinomaOpen Targets
0.01Suggestive
ovarian cancerOpen Targets
0.01Suggestive
chronic kidney diseaseOpen Targets
0.01Suggestive
Alzheimer diseaseOpen Targets
0.01Suggestive
hepatocellular carcinomaOpen Targets
0.00Suggestive
breast cancerOpen Targets
0.00Suggestive
ovarian serous adenocarcinomaOpen Targets
0.00Suggestive
septic shockOpen Targets
0.00Suggestive
cancerOpen Targets
0.00Suggestive
multiple myelomaOpen Targets
0.00Suggestive
polycystic ovary syndromeOpen Targets
0.00Suggestive
bladder transitional cell carcinomaOpen Targets
0.00Suggestive
esophageal cancerOpen Targets
0.00Suggestive
lung cancerOpen Targets
0.00Suggestive
sarcomaOpen Targets
0.00Suggestive
uterine corpus endometrial carcinomaOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
MORF4L1Protein interaction90%MRFAP1Protein interaction72%TSNAXProtein interaction70%
Tissue Expression6 tissues
Brain
100%
Heart
75%
Liver
55%
Ovary
52%
Bone Marrow
35%
Lung
35%
Gene Interaction Network
Click a node to explore
MRFAP1L1MORF4L1MRFAP1TSNAX
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt Q96HT8
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.37LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.79 [0.47–1.37]
RankingsWhere MRFAP1L1 stands among ~20K protein-coding genes
  • #13,018of 20,598
    Most Researched25
  • #14,277of 17,882
    Most Constrained (LOEUF)1.37
Genes detectedMRFAP1L1
Sources retrieved1 papers
Response timeβ€”
πŸ“„ Sources
1
1
Construction and Validation of a Prognostic Model Based on Pyroptosis-related Genes in Bladder Cancer.
PMID: 37849225
Comb Chem High Throughput Screen Β· 2024
1.00