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10 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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MRLN
myoregulin
Chromosome 10 · 10q21.2
NCBI Gene: 100507027Ensembl: ENSG00000227877.7HGNC: HGNC:48649UniProt: P0DMT0
5PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
enzyme inhibitor activitynegative regulation of calcium ion import into sarcoplasmic reticulumsarcoplasmic reticulum membraneendoplasmic reticulum membranethyroid cancerglomerulonephritisalcohol drinkingAbnormality of the skeletal system
✦AI Summary

The information provided is insufficient to write a comprehensive gene function summary for MRLN (myoregulin). The PubMed abstracts provided do not contain any studies specifically investigating the MRLN gene or myoregulin protein function. Instead, the abstracts discuss unrelated topics including nasopharyngeal carcinoma radiotherapy (where 'MRLN' refers to medial retropharyngeal lymph nodes), medical imaging techniques, rectal cancer, cholangiocarcinoma staging, classical swine fever virus, and lupus-related skin cancer. Only one abstract 1 mentions myoregulin in the context of sarcoplasmic reticulum calcium regulation in horses with exertional rhabdomyolysis, but provides no functional data about the MRLN gene itself. The study found identical coding sequences between affected and control horses, with no variants associated with the disease phenotype. Based solely on the provided abstracts, it is not possible to describe the primary function, mechanism, disease relevance, or clinical significance of the human MRLN gene, as no relevant functional studies are included in this literature set.

Sources cited
1
MRLN coding sequences were identical between horses with recurrent exertional rhabdomyolysis and controls, with no disease-associated variants found
PMID: 30720217
⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsⓘ20
thyroid cancerOpen Targets
0.11Weak
glomerulonephritisOpen Targets
0.10Weak
alcohol drinkingOpen Targets
0.10Suggestive
Abnormality of the skeletal systemOpen Targets
0.06Suggestive
Distal myopathy, Nonaka typeOpen Targets
0.05Suggestive
smoking initiationOpen Targets
0.05Suggestive
Alzheimer diseaseOpen Targets
0.05Suggestive
myopathy, distal, 5Open Targets
0.05Suggestive
acquired thrombocytopeniaOpen Targets
0.05Suggestive
exercise intolerance, riboflavin-responsiveOpen Targets
0.05Suggestive
Abnormality of the integumentOpen Targets
0.05Suggestive
HypocalcemiaOpen Targets
0.05Suggestive
GNE myopathyOpen Targets
0.04Suggestive
tibial muscular dystrophyOpen Targets
0.04Suggestive
myopathy, distal, 6, adult-onset, autosomal dominantOpen Targets
0.04Suggestive
hyperpituitarismOpen Targets
0.04Suggestive
tubular aggregate myopathyOpen Targets
0.04Suggestive
polyglucosan body myopathy type 2Open Targets
0.04Suggestive
myopathy, sarcoplasmic bodyOpen Targets
0.04Suggestive
Proximal spinal muscular atrophy type 4Open Targets
0.04Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
MYOD1Protein interaction96%STRIT1Protein interaction85%SLNProtein interaction76%
Tissue Expression6 tissues
Brain
100%
Lung
25%
Ovary
18%
Liver
9%
Heart
0%
Bone Marrow
0%
Gene Interaction Network
Click a node to explore
MRLNMYOD1STRIT1SLN
PROTEIN STRUCTURE
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AlphaFoldAI-predicted · UniProt P0DMT0
View on AlphaFold ↗
RankingsWhere MRLN stands among ~20K protein-coding genes
  • #18,368of 20,598
    Most Researched5
Genes detectedMRLN
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.
PMID: 36746459
BMJ · 2023
1.00
2
MRLN: Multi-Task Relational Learning Network for MRI Vertebral Localization, Identification, and Segmentation.
PMID: 31985447
IEEE J Biomed Health Inform · 2020
0.90
3
What is the predictive value of pretreatment MRI characteristics for achieving a complete response after total neoadjuvant treatment in locally advanced rectal cancer?
PMID: 39970545
Eur J Radiol · 2025
0.80
4
Endoscopic Ultrasound/Fine Needle Aspiration Is Effective for Lymph Node Staging in Patients With Cholangiocarcinoma.
PMID: 31860935
Hepatology · 2020
0.70
5
Coding sequences of sarcoplasmic reticulum calcium ATPase regulatory peptides and expression of calcium regulatory genes in recurrent exertional rhabdomyolysis.
PMID: 30720217
J Vet Intern Med · 2019
0.60