1 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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9PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingenzyme activator activityregulation of slow-twitch skeletal muscle fiber contractionregulation of ATPase-coupled calcium transmembrane transporter activityviral pneumoniainfluenzabronchopneumoniaLung Abscess
Based on limited published evidence, STRIT1 is a small transmembrane protein that regulates sarcoplasmic reticulum calcium handling in skeletal and cardiac muscle. STRIT1 enhances ATP2A1/SERCA1 and ATP2A2/SERCA2 ATPase activity by displacing inhibitory regulators, including phospholamban, sarcolipin, and myoregulin 1. The protein preferentially binds phosphorylated SERCA2 conformations during systolic calcium dynamics and can activate SERCA2 independently of phospholamban 1. STRIT1 increases sarcoplasmic reticulum calcium uptake and myocyte contractility, thereby regulating muscle contraction. Structural analysis confirms its role as a calcium regulation miniprotein 2.
1
STRIT1 enhances ATP2A2/SERCA2 ATPase activity, competes with and displaces phospholamban, and can activate SERCA2 in the absence of phospholamban
PMID: 335811122
Computational structural analysis supports known functions of STRIT1 as a calcium regulation miniprotein
PMID: 39974886⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
viral pneumoniaOpen Targets
bronchopneumoniaOpen Targets
Myasthenia gravisOpen Targets
facial morphologyOpen Targets
paramyotonia congenita of Von EulenburgOpen Targets
Duchenne muscular dystrophyOpen Targets
Thomsen and Becker diseaseOpen Targets
adolescent idiopathic scoliosisOpen Targets
myotonia congenita, autosomal recessiveOpen Targets
pancreatic adenocarcinomaOpen Targets
cardiomyopathyOpen Targets
diaphragm diseaseOpen Targets
breast carcinomaOpen Targets
dilated cardiomyopathyOpen Targets
heart failureOpen Targets
Autosomal dominant limb-girdle muscular dystrophy type 1COpen Targets
rippling muscle disease 2Open Targets
Brody myopathyOpen Targets
No pathogenic variants reported on ClinVar for this gene.