MYH10 encodes non-muscle myosin heavy chain IIB (NM IIB), a motor protein essential for actin-based cellular processes. The protein functions as a key regulator of cell migration, invasion, and cytoskeletal organization by forming actomyosin complexes 12. MYH10 plays crucial roles in cardiac lipid metabolism by connecting lipid droplets to the actin cytoskeleton, facilitating intracellular transport 3. During megakaryocyte development, MYH10 silencing contributes to endomitosis by causing cytokinesis failure through altered actomyosin accumulation at the cleavage furrow 4. The protein is also essential for primary cilia formation and Hedgehog signaling pathway regulation 5. Disease relevance includes neurodevelopmental disorders, where heterozygous variants cause intellectual disability and congenital anomalies through ciliary dysfunction 56. In cancer, MYH10 promotes tumor progression and chemoresistance by recruiting deubiquitinating enzymes and stabilizing oncogenic proteins like Snail 21. Recent studies identify MYH10 variants associated with ocular malformations including coloboma and ptosis without neurodevelopmental features, expanding the phenotypic spectrum 7. The protein's dysfunction affects multiple organ systems through disrupted cytoskeletal dynamics and signaling pathways.