NCAPH2 is a regulatory subunit of the condensin-2 complex that organizes chr22 during mitosis and interphase. The protein promotes mitotic chromosome 22 and facilitates resolution of DNA catenanes between sister chr22, likely by increasing tension to direct topoisomerase-mediated strand exchanges 1. Beyond its classical mitotic role, NCAPH2 localizes to telomeres where it interacts with the shelterin protein TRF1 to maintain telomere stability; NCAPH2 depletion triggers ATR-dependent DNA damage and sister-telomere fusions 1. Recent evidence suggests a role in replication origin firing in human cells 2. NCAPH2 also supports hematopoietic stem and progenitor cell development; condensin II subunits including NCAPH2 are essential for HSPC proliferation, with condensin II but not condensin I subunits required for this function 3. In Alzheimer's disease and amnestic mild cognitive impairment, peripheral NCAPH2 promoter methylation levels are significantly reduced and correlate with hippocampal atrophy, suggesting potential utility as a biomarker 4, 5. NCAPH2 expression is also associated with prognostic outcomes in serous ovarian cancer and hepatocellular carcinoma 6, 7.