NGF (nerve growth factor) is a critical neurotrophic protein that regulates neuronal survival, differentiation, and pain signaling through binding to its receptors TrkA and p75NTR 1. NGF functions as an extracellular ligand that activates cellular signaling cascades controlling neuronal proliferation and survival, with its immature precursor (proNGF) paradoxically promoting neuronal apoptosis rather than survival 2. Recent research reveals that neuropilin-1 (NRP1) serves as a crucial coreceptor that enhances NGF/TrkA signaling by chaperoning TrkA from biosynthetic pathways to plasma membrane and endosomes, forming a 2:2:2 stoichiometric complex 1. NGF expression is regulated by post-translational modifications, including HDAC6-dependent deacetylation that promotes NGF ubiquitination and degradation, which is essential for maintaining primordial follicle dormancy 3. Clinically, NGF levels are altered in various pathological conditions, with depletion observed in diabetic neuropathy correlating with sensory fiber dysfunction 4. NGF has demonstrated therapeutic potential in treating retinal neurodegenerative diseases, cutaneous ulcers, and corneal injuries 52. However, systemic NGF antibody treatments for chr1 pain have faced safety concerns, making the discovery of NRP1 as a targetable coreceptor particularly significant for developing safer nonopioid pain therapeutics 6.