NGFR encodes the p75 neurotrophin receptor (p75NTR), a low-affinity receptor that binds multiple neurotrophins including NGF, BDNF, NTF3, and NTF4, functioning as both a survival and death receptor for neural cells 1. The protein plays critical roles in neurodevelopment and neurodegeneration, with genetic variants associated with Alzheimer's disease risk and amyloid-β deposition in the brain 2. In tissue repair, NGFR contributes to healing processes, particularly in corneal ulcers and other wound types 1. Beyond neuronal functions, NGFR serves as a cell surface marker for skeletal muscle progenitor cells during human development and in human pluripotent stem cell differentiation 3. In cancer biology, melanoma-derived extracellular vesicles enriched in NGFR promote lymphangiogenesis and lymph node metastasis through ERK and NF-κB pathway activation, with NGFR expression in metastases correlating with patient survival 4. The receptor also marks specific bone marrow-derived mesenchymal stem cell populations involved in skeletal tissue maintenance 5. While some studies have investigated NGFR genetic polymorphisms in Parkinson's disease, definitive associations remain unclear 6.