NHP2 is a core component of the H/ACA small nucleolar ribonucleoprotein (snoRNP) complex essential for ribosome biogenesis and telomere maintenance 1. As part of this complex alongside Cbf5/Dyskerin, Nop10, and Gar1, NHP2 catalyzes pseudouridylation of rRNA by guiding the isomerization of uridine residues, which stabilizes rRNA conformation 1. NHP2 also participates in telomerase complex assembly and is required for proper processing and intranuclear trafficking of TERC, the RNA component of telomerase 2. Functionally, NHP2 deficiency impairs rRNA biogenesis and affects ribosomal subdomain assembly during early maturation events 34. Clinically, NHP2 mutations cause dyskeratosis congenita (DC), a multisystem inherited syndrome characterized by bone marrow failure, cancer predisposition, and mucocutaneous abnormalities 2. Biallelic NHP2 mutations cause Høyeraal-Hreidarsson syndrome, the severe form of DC 3. Heterozygous NHP2 mutations have also been identified in patients with pulmonary fibrosis, representing the broader spectrum of telomere-related diseases 35. Additionally, elevated NHP2 expression promotes uveal melanoma progression and associates with poor prognosis 6.