WRAP53 is a multifunctional RNA chaperone with critical roles in telomere maintenance and DNA repair. As an essential component of the telomerase holoenzyme complex, WRAP53 recognizes and binds the Cajal body box (CAB box) on telomerase RNA template component (TERC) and small Cajal body RNAs (scaRNAs) 12. It stimulates telomerase catalytic activity by controlling CR4/CR5 region folding in TERC and delivers telomerase to telomeres during S phase 2. Additionally, WRAP53 facilitates Cajal body formation and localization of scaRNAs 34. In DNA repair, WRAP53 is phosphorylated by ATM following DNA damage and relocates to double-strand break sites, recruiting ubiquitin ligase RNF8 to promote both homologous recombination and non-homologous end joining 56. WRAP53 expression is frequently elevated in various cancer types, and high levels correlate with poor prognosis in head and neck cancer 7. Cancer cells show enhanced sensitivity to WRAP53 depletion, with knockdown triggering mitochondrial apoptosis 7. Notably, WRAP53 also interacts with CTCF to regulate p53 expression 8, and differential effects of WRAP53 transcript variants on cancer cell behavior depend on p53 status 9. Dyskeratosis congenita mutations have been associated with WRAP53 dysfunction.