NHS (NHS actin remodeling regulator) is an X-linked gene that functions in cell morphology by maintaining circumferential actin ring integrity and controlling lamellipod formation. The gene was identified as the human homolog of Drosophila Guanylate-kinase holder (Gukh), an adaptor molecule bridging Discs large and Scribble proteins implicated in epithelial polarity establishment 1. NHS contains eight GUKH homology domains and a proline-rich domain, sharing 28.5% amino acid identity with the paralogous GUKH2 gene 1. The protein is involved in regulating eye, tooth, brain, and craniofacial development, with particular roles in lens development and cell differentiation through its effects on cell junction organization 1. Mutations in NHS cause Nance-Horan syndrome, an X-linked disorder characterized by developmental abnormalities, and are associated with congenital cataracts (Cataract 40) 1. Given that human homologs of Drosophila dlg and scrib function as cancer-associated genes, NHS and related GUKH proteins are predicted to have roles in cellular processes relevant to cancer biology 1. The gene's critical function in actin dynamics and developmental signaling makes it essential for proper morphogenesis and tissue organization during embryogenesis.