NMBR (neuromedin B receptor) is a G-protein-coupled receptor that mediates cellular responses to the neuropeptide neuromedin B (NMB) 1. Upon ligand binding, NMBR activates intracellular signaling cascades including phospholipase C activation, calcium mobilization, and protein kinase C activation 1. In physiological contexts, NMBR contributes to respiratory regulation, sneeze reflexes, itch sensation, and innate immune responses to influenza through modulation of interferon-alpha production. Clinically, NMBR has emerged as significant in cancer biology. Cervical cancer cells produce NMB, which activates NMBR on Schwann cells through PKA-mediated calcium signaling, reprogramming these cells to promote perineural invasion—a hallmark of advanced cervical cancer 2. Combined serum NMB and CCL2 measurements may predict perineural invasion to guide surgical planning 2. In lung cancer, NMBR is frequently overexpressed alongside related bombesin receptors and functions as a growth factor receptor, often in autocrine fashion 3. NMBR inhibition enhances cytotoxic drug efficacy and reduces cancer cell survival, while NMBR overexpression enables sensitive tumor localization and targeted therapy delivery 3. These findings position NMBR as a potential therapeutic target and diagnostic biomarker across multiple cancer types.