NOL8 (nucleolar protein 8) is a nucleolar protein containing an RNA recognition motif that serves multiple functions in cancer cell survival and ribosomal biogenesis. Structurally, NOL8 functions as a nucleolar anchoring protein for the DEAD-box RNA helicase DDX47, facilitating proper localization of DDX47 within the nucleolus and enabling recruitment of pre-rRNA processing proteins 1. This anchoring role suggests NOL8 participates in ribosome biogenesis through rRNA processing. In cancer pathology, NOL8 is specifically overexpressed in diffuse-type gastric cancer compared to intestinal-type gastric cancer 2. Functional studies demonstrate that NOL8 knockdown induces apoptosis in gastric cancer cell lines, establishing its role in cancer cell survival 2. Beyond gastric cancer, NOL8 promotes growth and migration in prostate cancer by enhancing beta-catenin/TCF4 signaling 3. Additionally, NOL8 was identified as a genetic modulator of dystrophin exon skipping in muscular dystrophy models 4. Genetically, NOL8 harbors rare deleterious variants nominally associated with clozapine-induced myocarditis susceptibility 5, and is regulated by microRNA-452 in colorectal cancer, where upregulated miR-452 suppresses NOL8 expression 6. These findings position NOL8 as a potential therapeutic target across multiple cancer types.